BOSENTAN NO FURTHER A MYSTERY

6 The phosphodiesterase-5 inhibitor sildenafil is certified for PAH in FC I–IV while in the USA and FC II–III in Europe. Endothelin receptor antagonists (ERAs) like bosentan, sitaxentan and ambrisentan are oral therapies certified for use in PAH. As no oral agent has proven superiority there remains debate as to which need to be utilized first